Views: 6 Author: Site Editor Publish Time: 2025-06-08 Origin: Site
In the pharmaceutical industry, cyclic compounds are essential raw materials widely used in drug synthesis, with their quality directly impacting the efficacy and safety of medicines. Drying such sensitive materials is a complex task that demands high precision and innovative technology.
Recently, one of our clients presented a requirement: to dry a specific cyclic compound used in pharmaceutical production. This material had an initial moisture content of 39%, consisting of both surface water and crystallization water, and needed to be dried to below 0.3%, ideally as low as possible. The challenge was compounded by the compound’s extreme sensitivity to temperature—rapid heating could cause it to melt—and its high flowability, which made it difficult for some traditional drying equipment to handle. Our Hollow Screw Vacuum Dryer proved to be the ideal solution, completing the task in just 2 hours while ensuring material quality and consistency.
This cyclic compound had an initial moisture content of 39%, comprising surface water and crystallization water. The low temperature threshold for surface water removal indicated its high thermal sensitivity; if the temperature rose too quickly, the material would melt and become unusable. Additionally, its excellent flowability posed further challenges. In traditional equipment, particularly single-cone ribbon dryers, the material tended to settle at the bottom, resulting in uneven heating, prolonged drying times, and inconsistent moisture levels. For the pharmaceutical industry, such inconsistencies are unacceptable, as uniformity is a core production requirement.
To meet the client’s needs, we designed a staged drying process:
The first step targeted surface water. Under vacuum conditions, when the material reached around 26°C, it began releasing moisture while avoiding damage to its integrity. Gradual operation was critical—hasty heating could destabilize the compound. After approximately 20 minutes, the surface water was largely removed.
After removing surface water, we focused on drying the crystallization water. This stage required a gradual temperature increase, precisely controlled to release bound moisture. About 1.5 hours later, no further moisture was released, and drying was complete.
Our hollow screw dryer, with its unique design and functionality, perfectly addressed this challenge:
Under vacuum, the boiling point of water is lowered, enabling drying at lower temperatures. This not only protected certain materials, especially heat-sensitive ones, from thermal damage but also significantly accelerated the drying process.
The built-in spiral agitator kept the material in constant motion, preventing accumulation at the bottom. For highly flowable materials, this design ensured even heat distribution, eliminating inconsistencies common in traditional equipment.
For this experiment with a 30kg batch, the hollow spiral dryer reduced moisture from 39% to below 0.3% in 2 hours. In contrast, other vacuum dryers required 6-8 hours, delivering a 3-4 times efficiency improvement, with consistently superior quality.
Previously, the client used a single-cone ribbon dryer with poor results. Due to material accumulation, drying was uneven, taking up to 8 hours, and moisture levels sometimes exceeded 0.3%, risking batch rejection. With the hollow screw dryer, the situation transformed: 30kg of material was uniformly dried in 2 hours, consistently meeting the stringent moisture standard. This not only saved time but also enhanced batch consistency—a critical factor in pharmaceutical production.
This case highlights several key advantages of our hollow screw dryer:
The vacuum system supports low-temperature operation, preserving the material’s structural integrity.
The screw agitation mechanism ensures even heat distribution, addressing the challenges of flowable materials.
The large heating area and significantly reduced processing time lower energy consumption and boost productivity.
Our hollow spiral dryer has a compact footprint, with the largest batch capacity of 5000L requiring only 6000×2100×4000 mm.
It can dry various liquids, powders, slurries, granules, and more, making it a versatile solution.
For the client, these advantages translated into an efficient, energy-saving, and reliable drying process, perfectly aligned with their production goals.
If your production line faces similar challenges, feel free to contact us to explore tailored solutions together.
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